If you are not going to go any bigger than 35's and you are not buying a 5th wheel camper or anything else huge and very wind resistant.
I would say leave the axle gearing alone and tow in 5th gear, locking 6th out of the equation.
I believe the final drive ratio is similar in 5th gear with 3.42's and 6th with 4.10's.
I don't think you are going to be happy with your unloaded highway cruising RPMs with the 4.10 gears at 80mph...
I really think 3.73 gears would have been ideal for these 3/4 ton trucks, but that small of a change probably isn't worth the financial investment. JMO
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